Oral corticosteroids are often the treatment of choice for non-responsive anterior, mediate and posterior uveitis. Prednisone 0.5 to 1 mg/kg (or up to 2mg/kg in moderate to severe cases) is recommended as initial therapy, followed by a slow head as declaration occurs. In most cases, an H2 receptor antagonist, such as ranitidine (ranitidine, GlaxoSmithKline) 150mg p.o.b.i.d. is prescribed concurrently to prevent secondary gastrointestinal problems, such as stomach upset and ulcers.
Unfortunately, oral corticosteroids are associated with other(a) well-known potential complications, including cataractogenesis, secondary glaucoma, sodium retention (leading to high blood pressure and edema), weight gain, headache, hirsutism (abnormal hairiness), impaired wound healing, osteoporosis, and worsening of diabetes. As with topical corticosteroid therapy, complications occur more frequently with high doses and prolonged treatment.
Periocular corticosteroid injections are another option for scratchy anterior uveitis or arbitrate uveitis (e.g., pars planitis). A small enumerate of depot corticosteroid, such as 1.0ml of 40mg/ml triamcinolone acetonide, whitethorn be injected into the periorbital region in such situations.
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While steroid injections circumvent many side effects associated with systemic corticosteroids, complications whitethorn still arise. IOP response is a particular concern, especially effrontery that medication cannot be removed as easily as an oral or topical preparation, which the patient can taper or discontinue.
A recent development for the management of intermediate and/or posterior uveitis is Retisert (fluocinolone acetonide 0.59mg, Bausch & Lomb), a sustained-release intra-vitreal corticosteroid implant. Reti-sert is indicated for the treatment of chronic, non
septic uveitis that affects the posterior segment of the eye.2 A new intravitrealdexamethasone implant is likewise under investigation.3
Unfortunately, patients treated with these devices can...If you want to get a rise essay, order it on our website: Orderessay
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