Bipolar Genetics

J Med Genet 1999;36:585594 585 Review article cistrontics of bipolar rowdyism Nick Craddock, Ian Jones Division of Neuroscience, University of Birmingham, Queen Elizabeth psychiatric Hospital, Mindelsohn Way, Birmingham B15 2QZ, UK N Craddock I Jones Abstract Bipolar disturb (also cognise as manic depressive illness) is a complex transmittable disorder in which the core feature is pa thatlogical disturbance in sense of humour (aVect) ranging from extreme elation, or mania, to severe depression usually accompanied by disturbances in thinking and behaviour. The life sentence prevalence of 1% is equal in males and females and family, twin, and adoption studies domiciliate robust evidence for a study genetic contri plainlyion to risk. there argon methodological impediments to precise quanti?cation, nevertheless the approximate life story risk of bipolar disorder in relatives of a bipolar proband are: monozygotic co-twin 40-70%; ?rst d egree relative 5-10%; orthogonal mortal 0.5-1.5%. Occasional families may exist in which a unity gene plays the major role in determining susceptibility, tho the majority of bipolar disorder involves the interaction of multiple genes (epistasis) or more than complex genetic mechanisms (such as dynamic transformation or imprinting).

Molecular genetic positional and aspect gene approaches are being used for the genetic dissection of bipolar disorder. No gene has tho been identi?ed scarce promising ?ndings are emerging. Regions of interest identi?ed in gene linkage studies implicate 4p16, 12q23-q24, 16p13, 21q22, and Xq24-q26. Chromosome 18 is also of interest but the ?ndings are mistake with up to three possi! ble regions implicated. To date most campaigner gene studies let focused on neurotransmitter systems in?uenced by medication used in clinical management of the disorder but no robust positive ?ndings have yet emerged. It is, however, almost legitimate that over the next few years bipolar susceptibility genes will be identi?ed. This will have a...If you want to get a all-inclusive essay, order it on our website: OrderEssay.net

If you want to get a full information about our service, visit our page: write my essay